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Literature summary for 3.4.22.47 extracted from

  • Furuta, N.; Takeuchi, H.; Amano, A.
    Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment (2009), Infect. Immun., 77, 4761-4770.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.47

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle Porphyromonas gingivalis secretes outer membrane vesicles that contain major virulence factors, including Arg-gingipain and Lys-gingipain Porphyromonas gingivalis 31982
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
focal adhesion kinase + H2O Porphyromonas gingivalis Kgp is responsible for degradation of integrin-related molecules ?
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 ?
paxillin + H2O Porphyromonas gingivalis Kgp is responsible for degradation of integrin-related molecules ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
focal adhesion kinase + H2O Kgp is responsible for degradation of integrin-related molecules Porphyromonas gingivalis ?
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 ?
paxillin + H2O Kgp is responsible for degradation of integrin-related molecules Porphyromonas gingivalis ?
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 ?

Synonyms

Synonyms Comment Organism
KGP
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 Porphyromonas gingivalis
Lys-gingipain
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 Porphyromonas gingivalis

General Information

General Information Comment Organism
malfunction Porphyromonas gingivalis secretes outer membrane vesicles that contain major virulence factors, including Arg-gingipain and Lys-gingipain. Kgp-null membrane vesicles enter the cells and degrade transferrin receptor, while they scarcely degrade paxillin and focal adhesion kinase Porphyromonas gingivalis
physiological function following entry of Porphyromonas gingivalis membrane vesicles into host cells, membrane vesicle-associated gingipains degrade cellular functional molecules such as transferrin receptor and paxillin/FAK, resulting in cellular impairment, indicating that Porphyromonas gingivalis membrane vesicles are potent vehicles for transmission of virulence factors into host cells Porphyromonas gingivalis