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Literature summary for 3.4.22.47 extracted from

  • Ishiguro, I.; Saiki, K.; Konishi, K.
    PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system (2009), FEMS Microbiol. Lett., 292, 261-267.
    View publication on PubMed
Search for more literature for 3.4.22.47

Activating Compound

Activating Compound Comment Organism Structure
additional information membrane protein PG27 is essential for secretion of gingipains and their extracellular activity, and is localized in both the inner and outer membranes Porphyromonas gingivalis

Protein Variants

Protein Variants Comment Organism
additional information in the gene PG0027, encoding protein PG27, deletion mutant 83K10, the activities of Arg-gingipain and Lys-gingipain are severely reduced, while the activities of secreted exopeptidases DPPIV, DPP-7, and PTP-A are unaffected Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
additional information in the gene PG0027, encoding protein PG27, deletion mutant 83K10, the activities of Arg-gingipain and Lys-gingipain are severely reduced, while the activities of secreted exopeptidases DPPIV, DPP-7, and PTP-A are unaffected Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Porphyromonas gingivalis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis the membrane protein PG27, encoded by gene PG0027, is essential for the secretion of gingipains, overview ?
-
 ?
additional information Porphyromonas gingivalis W83 the membrane protein PG27, encoded by gene PG0027, is essential for the secretion of gingipains, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis W83
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the membrane protein PG27, encoded by gene PG0027, is essential for the secretion of gingipains, overview Porphyromonas gingivalis ?
-
 ?
additional information the membrane protein PG27, encoded by gene PG0027, is essential for the secretion of gingipains, overview Porphyromonas gingivalis W83 ?
-
 ?
N-alpha-benzyloxycarbonyl-L-lysine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzyloxycarbonyl-L-lysine + 4-nitroaniline
-
 ?
N-alpha-benzyloxycarbonyl-L-lysine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis W83 N-alpha-benzyloxycarbonyl-L-lysine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
KGP
-
 Porphyromonas gingivalis
Lys-gingipain
-
 Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Porphyromonas gingivalis