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Literature summary for 3.4.22.38 extracted from

  • Qiu, Z.C.; Dong, X.L.; Dai, Y.; Xiao, G.K.; Wang, X.L.; Wong, K.C.; Wong, M.S.; Yao, X.S.
    Discovery of a new class of cathepsin K inhibitors in Rhizoma Drynariae as potential candidates for the treatment of osteoporosis (2016), Int. J. Mol. Sci., 17, E2116 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
kushennol F shows inhibitory effects on the bone resorption process related to cathepsin K Homo sapiens
Phe-Phe-fluoromethylketone
-
 Homo sapiens
sophoraflavanone G shows inhibitory effects on the bone resorption process related to cathepsin K Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P43235
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000047
-
 pH and temperature not specified in the publication Homo sapiens Phe-Phe-fluoromethylketone
0.00879
-
 pH and temperature not specified in the publication Homo sapiens kushennol F
0.0272
-
 pH and temperature not specified in the publication Homo sapiens sophoraflavanone G

General Information

General Information Comment Organism
metabolism the enzyme accounts for the increase in bone resorption in metabolic bone disorders such as postmenopausal osteoporosis Homo sapiens