Literature summary for 3.4.22.38 extracted from

Kruglyak, N.; Williams, D.E.; Chen, H.; Law, S.; Kaleta, J.; Villanueva, I.; Davies, J.E.; Andersen, R.J.; Broemme, D.
Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K (2017), Bioorg. Med. Chem. Lett., 27, 1397-1400 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
leupeptazin	isolated from a liquid culture of soil Streptomyces sp. IS2-4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.044	-	leupeptazin	pH and temperature not specified in the publication	Homo sapiens

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Release 2023.1 (January 2023)