Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protease-activated receptor-1 + H2O | Porphyromonas gingivalis | specific substrate for Arg-gingipain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protease-activated receptor-1 + H2O | specific substrate for Arg-gingipain | Porphyromonas gingivalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arg-gingipain | - |
Porphyromonas gingivalis |
RGP | - |
Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
malfunction | human keratinocyte Rgp-deficient and Kgp-deficient double mutant cells do not cleave protease-activated recptor-1 and -2. The single Rgp-negative mutant cleaves protease-activated recptor-2 | Porphyromonas gingivalis |
physiological function | Rgp-cleavage of protease-activated receptor-1 up-regulates expression of cytokines | Porphyromonas gingivalis |