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Literature summary for 3.4.22.37 extracted from

  • Inomata, M.; Ishihara, Y.; Matsuyama, T.; Imamura, T.; Maruyama, I.; Noguchi, T.; Matsushita, K.
    Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis (2009), J. Periodontol., 80, 1511-1517.
    View publication on PubMed
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
Phe-Pro-Arg-chloromethylketone
-
 Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-L-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis benzoyl-L-arginine + 4-nitroaniline
-
 ?
thrombomodulin + H2O Lys-gingipain and Arg-gingipain cleave thrombomodulin in vitro Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
RGP
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

General Information

General Information Comment Organism
physiological function gingipains induce the degradation and inactivation of endothelial thrombomodulin which may promote vascular coagulation and inflammation Porphyromonas gingivalis