Literature summary for 3.4.21.B7 extracted from

Jenny, L.; Dobo, J.; Gal, P.; Schroeder, V.
MASP-1 of the complement system promotes clotting via prothrombin activation (2015), Mol. Immunol., 65, 398-405 .

Search for more literature for 3.4.21.B7

Inhibitors

Inhibitors	Comment	Organism	Structure
SGMI-1	selective MASP-1 inhibitor, based on the Schistocerca gregaria protease inhibitor scaffold	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P48740	-	-

General Information

General Information	Comment	Organism
physiological function	addition of recombinant active MASP-1 to a a microvascular, whole blood flow model results in accelerated fibrin clot formation while addition of inhibitor SGMI-1 delays it. MASP-1 inhibition and especially inhibition of both lectin pathway and complement pathway significantly diminishes fibrin deposition upon complement activation	Homo sapiens

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Release 2023.1 (January 2023)