Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform mannan-binding lectin-associated serine protease 2 + H2O | Homo sapiens | enzyme MASP-1 is the main activator of MASP-2 | mature mannan-binding lectin-associated serine protease 2 + ? | - |
? | |
proform protease activated receptor 4 + H2O | Homo sapiens | activation | mature protease activated receptor 4 + ? | - |
? | |
prothrombin + H2O | Homo sapiens | enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393 | thrombin a + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P48740 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform mannan-binding lectin-associated serine protease 2 + H2O | activation | Homo sapiens | mature mannan-binding lectin-associated serine protease 2 + ? | - |
? | |
proform mannan-binding lectin-associated serine protease 2 + H2O | enzyme MASP-1 is the main activator of MASP-2 | Homo sapiens | mature mannan-binding lectin-associated serine protease 2 + ? | - |
? | |
proform protease activated receptor 4 + H2O | activation | Homo sapiens | mature protease activated receptor 4 + ? | - |
? | |
prothrombin + H2O | enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393 | Homo sapiens | thrombin a + ? | - |
? | |
prothrombin + H2O | enzyme MASP-1 cleaves prothrombinant three cleavage sites | Homo sapiens | thrombin a + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MASP-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme MASP-1 is part of the lectin pathway of the complement system and is able to induce and promote clot formation, MASP-1-induced clotting is dependent on prothrombin | Homo sapiens |