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Literature summary for 3.4.21.B7 extracted from
- Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1 (2011), PLoS ONE, 6, e20036.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C1-inhibitor | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | Homo sapiens | - |
bradykinin + ? | - |
? |  |
| low-molecular-weight kininogen + H2O | Homo sapiens | the cleavage rate of low-molecular-weight kininogen by MASP-1 is about 5times lower than that of kininogen | ? | - |
? | |
| additional information | Homo sapiens | MASP-1 cannot cleave complement component C4, recombinant MASP-1 does not activate plasma prekallikrein | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | - |
Homo sapiens | bradykinin + ? | - |
? | |
| low-molecular-weight kininogen + H2O | the cleavage rate of low-molecular-weight kininogen by MASP-1 is about 5times lower than that of kininogen | Homo sapiens | ? | - |
? | |
| additional information | MASP-1 cannot cleave complement component C4, recombinant MASP-1 does not activate plasma prekallikrein | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MASP-1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the bradykinin production by MASP-1 may contribute to the pro-inflammatory effect of the lectin pathway of complement and to the elevated bradykinin levels in hereditary angioedema patients | Homo sapiens |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
kininogen | recombinant MASP-1, at pH 7.8 and 37°C | Homo sapiens |
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