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Literature summary for 3.4.21.B7 extracted from
- Mannan-binding-lectin-associated serine proteases, characteristics and disease associations (2005), Semin. Immunopathol., 27, 299-319.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-2-Macroglobulin | - |
Homo sapiens | |
| antithrombin III | inhibitory in the presence of heparin on activity of MASP-1 | Homo sapiens | |
| C1 inhibitor | inhibitory in the presence of heparin on activity of MASP-1 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
Western blot analysis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Homo sapiens | - |
| blood plasma | - |
Homo sapiens | - |
| liver | primary site of MASP-1 synthesis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | - |
Homo sapiens | ? | - |
? |  |
| complement component C3 + H2O | cleavage with low efficiency | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MASP-1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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