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Literature summary for 3.4.21.B60 extracted from

  • Kapczynski, D.R.; Sweeney, R.; Spackman, E.; Pantin-Jackwood, M.; Suarez, D.L.
    Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells (2022), Virology, 569, 1-12 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B60

Application

Application Comment Organism
medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Mesocricetus auratus
medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Felis catus
medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Capra hircus
medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells. Permissive replication of SARS-CoV-2 is not found in pig or horse. Cells expressing genes from either bat species tested demonstrate temporal replication of SARS-CoV-2 that peaks early and is not sustained Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in in the avian fibroblast cell line, DF1 Mesocricetus auratus
expression in in the avian fibroblast cell line, DF1 Felis catus
expression in in the avian fibroblast cell line, DF1 Homo sapiens
expression in in the avian fibroblast cell line, DF1 Capra hircus

Organism

Organism UniProt Comment Textmining
Capra hircus A0A452FYA6
-
-
Felis catus Q56H28
-
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Homo sapiens O15393
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Mesocricetus auratus
-
-
-

Synonyms

Synonyms Comment Organism
TMPRSS2
-
 Mesocricetus auratus
TMPRSS2
-
 Felis catus
TMPRSS2
-
 Capra hircus