Literature summary for 3.4.21.B60 extracted from

Bai, X.; Buckle, A.M.; Vladar, E.K.; Janoff, E.N.; Khare, R.; Ordway, D.; Beckham, D.; Fornis, L.B.; Majluf-Cruz, A.; Fugit, R.V.; Freed, B.M.; Kim, S.; Sandhaus, R.A.; Chan, E.D.
Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19 (2022), Sci. Rep., 12, 5207 .

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in HEK-293T cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-1-antitrypsin	the reactive center loop of alpha-1-antitrypsin adopts an inhibitory-competent conformation compared with the crystal structure of TMPRSS2 bound to nafamostat or HAI-2 TMPRSS2 inhibitor. Negatively-charged heparin bridges adjacent electropositive patches at the TMPRSS2-alpha-1-antitrypsin interface, neutralizing otherwise repulsive forces. Heparinoid enoxaparin enhances alpha-1-antitrypsin inhibition of both TMPRSS2 activity and infection of human airway epithelial cells with coronavirus HCoV-229E	Homo sapiens
enoxaparin	heparinoid enoxaparin enhances alpha-1-antitrypsin inhibition of both TMPRSS2 activity and infection of human airway epithelial cells with coronavirus HCoV-229E	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Synonyms

Synonyms	Comment	Organism
TMPRSS2	-	Homo sapiens

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Release 2023.1 (January 2023)