Literature summary for 3.4.21.B60 extracted from

Chen, Y.; Yang, W.; Chen, H.; Huang, L.; Gao, J.; Lin, C.; Wang, Y.; Yang, C.; Liu, Y.; Hou, M.; Tsai, C.; Chou, Y.; Huang, B.; Hung, C.; Hung, Y.; Wang, W.; Su, W.; Kumar, V.; Wu, Y.; Chao, S.; Chang, C.; Chen, J.; Chiang, Y.; Cho, D.; Jeng, L.; Tsai, C.
Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2 (2022), J. Biol. Chem., 298, 101658 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-amine	compound exhibits a nearly effective TMPRSS2 inhibitory activity relative to tafenoquine , while it is deficient in SARS-CoV-2 main protease inhibition	Homo sapiens
tafenoquine	inhibits TMPRSS2 protease activity, tafenoquine may block SARS-CoV-2 by inhibiting enzymatic activities of both SARS-CoV-2 main protease and host TMPRSS2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)