Literature summary for 3.4.21.B6 extracted from

Selzer-Plon, J.; Bornholdt, J.; Friis, S.; Bisgaard, H.C.; Lothe, I.M.; Tveit, K.M.; Kure, E.H.; Vogel, U.; Vogel, L.K.
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis (2009), BMC Cancer, 9, 201.

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Activating Compound

Activating Compound	Comment	Organism	Structure
matriptase	prostasin is proteolytically activated by matriptase	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
hepatocyte growth factor activator inhibitor-1A	-	Homo sapiens
hepatocyte growth factor activator inhibitor-1B	-	Homo sapiens
Protease nexin-1	also known as glia-derived nexin or serpin E2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	the mRNA level of prostasin is slightly but significantly decreased in both mild/moderate dysplasia and severe dysplasia and in carcinomas compared to normal tissue from the same individual	up

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Release 2023.1 (January 2023)