Literature summary for 3.4.21.B6 extracted from

Tuyen, d.o.G.; Kitamura, K.; Adachi, M.; Miyoshi, T.; Wakida, N.; Nagano, J.; Nonoguchi, H.; Tomita, K.
Inhibition of prostasin expression by TGF-beta1 in renal epithelial cells (2005), Kidney Int., 67, 193-200.

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Cloned(Commentary)

Cloned (Comment)	Organism
subcloned into pGEM-T easy vector, subcloned into pGL3-basic vector and expressed in M-1 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
TGF-beta1	suppresses prostasin promoter activity in a time- and concentration-dependent manner, inhibition of prostasin expression by the induction of IkappaBalpha and the subsequent inhibition of NF-kappaB/Rel activity, may inhibit sodium reabsorption through a reduction in prostasin expression and subsequent inhibition of ENaC activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
renal epithelium	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)