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Literature summary for 3.4.21.B43 extracted from

  • Kryza, T.; Parent, C.; Pardessus, J.; Petit, A.; Burlaud-Gaillard, J.; Reverdiau, P.; Iochmann, S.; Labas, V.; Courty, Y.; Heuze-Vourch, N.
    Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrix (2018), Sci. Rep., 8, 6331 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B43

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 Abz-GMQWLKTQGN-(3-NO2-Tyr) 37°C, pH 7.5 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Homo sapiens the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration. KLK12-mediated fibronectin proteolysis antagonizes fibronectin polymerization and fibronectin fibril formation by endothelial cells, leading to an increase in cell migration ?
-
 ?
tenascin + H2O Homo sapiens the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKR0
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GMQWLKTQGN-(3-NO2-Tyr) + H2O
-
 Homo sapiens ?
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
Fibronectin + H2O the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration. KLK12-mediated fibronectin proteolysis antagonizes fibronectin polymerization and fibronectin fibril formation by endothelial cells, leading to an increase in cell migration Homo sapiens ?
-
 ?
additional information Abz-GPFTDVRAAVY-(3-NO2-Tyr) is not efficiently hydrolyzed Homo sapiens ?
-
 ?
tenascin + H2O
-
 Homo sapiens ?
-
 ?
tenascin + H2O the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
KLK12
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.45
-
 Abz-GMQWLKTQGN-(3-NO2-Tyr) 37°C, pH 7.5 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme stimulates endothelial cell migration by remodeling the fibronectin matrix Homo sapiens