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Literature summary for 3.4.21.B43 extracted from

  • Kryza, T.; Lalmanach, G.; Lavergne, M.; Lecaille, F.; Reverdiau, P.; Courty, Y.; Heuze-Vourch, N.
    Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor (2013), Biol. Chem., 394, 385-391.
    View publication on PubMed
Search for more literature for 3.4.21.B43

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKR0 gene KLK12
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
lung lung endothelial microvascular cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-ISLMKYRPPGF-(3-NO2)-Tyr + H2O very low activity Homo sapiens ?
-
 ?
Abz-SPFRSSR-(3-NO2)-Tyr + H2O low activity Homo sapiens ?
-
 ?
high molecular weight kininogen + H2O proteolysis pattern, overview. Release of bradykinin, a fragment containing the C-terminal end of kinins. The kininogenase activity of the enzyme is poor due to the resistance of hydrolysis of the K-R bond on the N-terminal side of the bradykinin sequence in the kininogen Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 12
-
 Homo sapiens
KLK12
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function proangiogenic activity of the enzyme in lung endothelial cells. The enzyme may interfere with kininostatin-related antiangiogenic activity by cleaving the D5 domain Homo sapiens