Literature summary for 3.4.21.B4 extracted from

Sharma, M.; Merkulova, Y.; Raithatha, S.; Parkinson, L.G.; Shen, Y.; Cooper, D.; Granville, D.J.
Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1 (2016), FEBS J., 283, 1734-1747 .

Search for more literature for 3.4.21.B4

Inhibitors

Inhibitors	Comment	Organism	Structure
inter-alpha-inhibitor protein	physiological inhibitor, significantly inhibits catalytic activity in vitro	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49863	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	extracellular granzyme K proteolytically activates protease-activated receptor-1 leading to increased interleukin 6 and monocyte chemotactic protein 1 production in endothelial cells. Granzyme K also increases tumour necrosis factor alpha-induced inflammatory adhesion molecule expression	Homo sapiens

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Release 2023.1 (January 2023)