Literature summary for 3.4.21.B28 extracted from

Ramirez-Montagut, T.; Blachere, N.E.; Sviderskaya, E.V.; Bennett, D.C.; Rettig, W.J.; Garin-Chesa, P.; Houghton, A.N.
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor (2004), Oncogene, 23, 5435-5446.

Search for more literature for 3.4.21.B28

Application

Application	Comment	Organism
medicine	tumor suppressor that abrogates tumorigenicity through regulation of cell growth and survival, in vitro, FAP expression restores contact inhibition, leads to cell cylcle arrest at G0/G1 phase, increases susceptibility to stress-induced apoptosis, and leads to caspase activation	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
subcloned into tetracyline-inducible vectors	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
S624A	FAP serine mutant lacking enzymatic activity, as wild type does not rescue dipeptidyl peptidase IV cell surface expression but is a more potent tumor suppressor than the wild type	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6	-
Mus musculus C57BL/6	-	C57BL/6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Mus musculus	-
fibroblast	-	Mus musculus	-
melanocyte	-	Mus musculus	-
additional information	not expressed in melanomas	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
FAP	-	Mus musculus
FAPalpha	-	Mus musculus

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Release 2023.1 (January 2023)