Literature summary for 3.4.21.B27 extracted from

Bhattacharjya, S.; Xu, P.; Zhong, M.; Chretien, M.; Seidah, N.G.; Ni, F.
Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7 (2000), Biochemistry, 39, 2868-2877.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EAVLAKHEAVRWHSEQRLLKRAKR	C-terminal region of the PC7 prosegment, strong inhibition, competitive	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pERTKR-4-methylcoumarin 7-amide + H2O	-	Rattus norvegicus	pERTKR + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
PC7	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000007	-	EAVLAKHEAVRWHSEQRLLKRAKR	pH 7	Rattus norvegicus

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Release 2023.1 (January 2023)