Literature summary for 3.4.21.B26 extracted from

Lee, S.; Lee, D.; Lee, M.; Yoon, J.
Proprotein convertase 5/6A is associated with bone morphogenetic protein-2-induced squamous cell differentiation (2015), Am. J. Respir. Cell Mol. Biol., 52, 749-761 .

Search for more literature for 3.4.21.B26

Application

Application	Comment	Organism
medicine	PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway, pointing to a potential therapeutic target for the prevention of chronic airway diseases that exhibit squamous metaplasia	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92824	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
nasal epithelium cell line	significant increase in the expression of PC5/6A in a retinoic acid deficiency-induced squamous metaplasia model of cultured human nasal epithelial cells	Homo sapiens	-
nasal polyp	highly expressed in metaplastic squamous epithelium of human nasal polyps	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PC5/6A	-	Homo sapiens
proprotein convertase 5/6A	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	decanoyl-Arg-Val-Lys-Arg-chloromethylketone decreases expression of PC5/6A	down

General Information

General Information	Comment	Organism
malfunction	specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases BMP-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers	Homo sapiens
physiological function	involvement of PC5/6A in squamous differentiation of human nasal epithelial cells. Overexpression of PC5/6A and BMP-2 in the human nasal epithelial cell line RPMI-2650 demonstrates that PC5/6A can activate BMP-2	Homo sapiens

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Release 2023.1 (January 2023)