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Literature summary for 3.4.21.B25 extracted from
- Proprotein convertase PACE4 (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1871-1874.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | PACE4 contributes to prohormone processing under some circumstances | Aplysia sp. |
| additional information | PACE4 is crucial to normal adipocyte differentation | Mus musculus |
| additional information | the pattern of PACE4 expression in development suggests a role in the extracellular actions or activation of inductive signals | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | alpha1-proteinase inhibitor-Portland and alpha1-proteinase inhibitor-Pittsburgh have little effect on PACE4 activity | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aplysia sp. | - |
- |
- |
| Homo sapiens | P29122 | - |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | Q63415 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | Purkinje cells, highest levels | Rattus norvegicus | - |
| gut | - |
Rattus norvegicus | - |
| gut | lower levels | Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| HEK-293 cell | - |
Homo sapiens | - |
| kidney | lower levels | Homo sapiens | - |
| kidney | lower levels | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| liver | lower levels | Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| lung | lower levels | Homo sapiens | - |
| additional information | 3T3 cell | Mus musculus | - |
| additional information | secretory vesicle | Aplysia sp. | - |
| additional information | subcortical nucleus | Rattus norvegicus | - |
| nervous system | high levels | Rattus norvegicus | - |
| neuroendocrine cell | - |
Rattus norvegicus | - |
| pituitary gland cell line | highest levels | Rattus norvegicus | - |
| spleen | lower levels | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| envelope glycoprotein gp160 | well activated by PaCE4 | Homo sapiens | ? | - |
? |  |
| additional information | does not cleave proopiomelanocortin, proglucagon, prosomatostatin and secretogranin in neuroendocrine cells | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PACE4 | - |
Mus musculus |
| PACE4 | - |
Aplysia sp. |
| PACE4 | - |
Homo sapiens |
| PACE4 | - |
Rattus norvegicus |
| paired basic amino-acid-cleaving enzyme-4 | - |
Rattus norvegicus |
| PC7 | - |
Rattus norvegicus |
| SPC4 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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