Cloned (Comment) | Organism |
---|---|
recombinant expression using the Leishmania tarentolae expression system | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CRES peptides | development of PC4 inhibitors based onthe CRES reactive site loop, miniserpin inhibitors, sequences, overview | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
acrosome | - |
Mammalia | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mammalia | PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | ovarian | Mammalia | - |
placenta | - |
Mammalia | - |
sperm | - |
Mammalia | - |
spermatocyte | - |
Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 | Mammalia | ? | - |
? | |
additional information | PC4 cleaves peptide bonds in the sequence R/K/H-X-X/R/K/-R, with X being any amino acid except cysteine, a preferred motif is KXKR | Mammalia | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC4 | - |
Mammalia |
General Information | Comment | Organism |
---|---|---|
physiological function | PC4 activates everal protein precursors in the secretory pathway of mammalian reproduction system with a vital role in fertilization and sperm maturation | Mammalia |