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Literature summary for 3.4.21.B12 extracted from

  • Fuhrman-Luck, R.A.; Stansfield, S.H.; Stephens, C.R.; Loessner, D.; Clements, J.A.
    Prostate cancer-associated kallikrein-related peptidase 4 activates matrix metalloproteinase-1 and thrombospondin-1 (2016), J. Proteome Res., 15, 2466-2478 .
    View publication on PubMed
Search for more literature for 3.4.21.B12

Inhibitors

Inhibitors Comment Organism Structure
alpha2-antiplasmin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
matrix metalloproteinase-1 + H2O Homo sapiens the enzyme activates matrix metalloproteinase-1, a protease that promotes prostate tumor growth and metastasis. Matrix metalloproteinase-1 is produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 at this site ?
-
 ?
thrombospondin-1 + H2O Homo sapiens the enzyme liberates an N-terminal product, with purported angiogenic activity, from thrombospondin-1. It cleaves thrombospondin-1 in osteoblast-derived matrix ?
-
 ?
urokinase-type plasminogen activator + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5K2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Arg-7-amido-4-trifluoromethyl coumarin + H2O
-
 Homo sapiens D-Val-Leu-Arg + 7-amino-4-trifluoromethyl coumarin
-
 ?
matrix metalloproteinase-1 + H2O
-
 Homo sapiens ?
-
 ?
matrix metalloproteinase-1 + H2O the enzyme activates matrix metalloproteinase-1, a protease that promotes prostate tumor growth and metastasis. Matrix metalloproteinase-1 is produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 at this site Homo sapiens ?
-
 ?
thrombospondin-1 + H2O
-
 Homo sapiens ?
-
 ?
thrombospondin-1 + H2O the enzyme liberates an N-terminal product, with purported angiogenic activity, from thrombospondin-1. It cleaves thrombospondin-1 in osteoblast-derived matrix Homo sapiens ?
-
 ?
urokinase-type plasminogen activator + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 4
-
 Homo sapiens
KLK4
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism KLK4 activates matrix metalloproteinase-1, a protease that promotes prostate tumor growth and metastasis. It is a potential multifunctional regulator of prostate cancer progression Homo sapiens