BRENDA - Enzyme Database
show all sequences of 3.4.21.B12

Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts

Ryu, O.; Hu, J.C.; Yamakoshi, Y.; Villemain, J.L.; Cao, X.; Zhang, C.; Bartlett, J.D.; Simmer, J.P.; Eur. J. Oral Sci. 110, 358-365 (2002)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
no activation of recombinant zymogen by native KLK4 enzyme in vitro
Sus scrofa
recombinant pig enamelysin
can activate the recombinant zymogen in vitro
Sus scrofa
Thermolysin
can activate the recombinant zymogen in vitro
Sus scrofa
Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Escherichia coli strain AD 494 (DE3) with and without the pro-peptide; expression in Spodoptera frugiperda SF9 cells via transfection with baculovirus; expression of inactive zymogen in human 293 kidney cells
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28000
-
x * 28000, deglycosylated enzyme, SDS-PAGE
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Sus scrofa
enzyme participates in the degradation of enamel proteins in vivo
?
-
-
-
polypeptide + H2O
Sus scrofa
-
peptides
-
Sus scrofa
?
Organism
Organism
UniProt
Commentary
Textmining
Sus scrofa
Q9XSN6
gene KLK4
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
2 N-glycosylated forms of different MW: 34 kDa and 37 kDa; deglycosylation abolishes enzyme activity
Sus scrofa
proteolytic modification
no activation of recombinant zymogen by native KLK4 enzyme in vitro; recombinant zymogen can be activated in vitro by thermolysin and by recombinant pig enamelysin
Sus scrofa
Purification (Commentary)
Purification (Commentary)
Organism
native enzyme from developing teeth; recombinant enzyme from 293 kidney cells
Sus scrofa
Reaction
Reaction
Commentary
Organism
Reaction ID
proteolysis of polypeptides
enzyme is a serine protease
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
enamel
transition-stage developing matrix
Sus scrofa
-
tooth
-
Sus scrofa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
amelogenin + H2O
recombinant substrate from pig expressed in Escherichia coli strain XL-1 blue as His-tagged protein
647339
Sus scrofa
amelogenin fragments
product identification by N-terminal sequencing and mass spectrometry
647339
Sus scrofa
-
casein + H2O
zymograph assay
647339
Sus scrofa
?
-
-
-
?
Gelatin + H2O
zymograph assay
647339
Sus scrofa
?
-
-
-
?
additional information
recombinant zymogen can be activated by thermolysin
647339
Sus scrofa
?
-
-
-
-
additional information
enzyme participates in the degradation of enamel proteins in vivo
647339
Sus scrofa
?
-
-
-
-
polypeptide + H2O
-
647339
Sus scrofa
peptides
-
647339
Sus scrofa
?
Subunits
Subunits
Commentary
Organism
?
x * 28000, deglycosylated enzyme, SDS-PAGE; x * 34000-37000, glycosylated enzyme, 2 glycosylation forms, SDS-PAGE
Sus scrofa
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Sus scrofa
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
no activation of recombinant zymogen by native KLK4 enzyme in vitro
Sus scrofa
recombinant pig enamelysin
can activate the recombinant zymogen in vitro
Sus scrofa
Thermolysin
can activate the recombinant zymogen in vitro
Sus scrofa
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli strain AD 494 (DE3) with and without the pro-peptide; expression in Spodoptera frugiperda SF9 cells via transfection with baculovirus; expression of inactive zymogen in human 293 kidney cells
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28000
-
x * 28000, deglycosylated enzyme, SDS-PAGE
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Sus scrofa
enzyme participates in the degradation of enamel proteins in vivo
?
-
-
-
polypeptide + H2O
Sus scrofa
-
peptides
-
Sus scrofa
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
2 N-glycosylated forms of different MW: 34 kDa and 37 kDa; deglycosylation abolishes enzyme activity
Sus scrofa
proteolytic modification
no activation of recombinant zymogen by native KLK4 enzyme in vitro; recombinant zymogen can be activated in vitro by thermolysin and by recombinant pig enamelysin
Sus scrofa
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme from developing teeth; recombinant enzyme from 293 kidney cells
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
enamel
transition-stage developing matrix
Sus scrofa
-
tooth
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
amelogenin + H2O
recombinant substrate from pig expressed in Escherichia coli strain XL-1 blue as His-tagged protein
647339
Sus scrofa
amelogenin fragments
product identification by N-terminal sequencing and mass spectrometry
647339
Sus scrofa
-
casein + H2O
zymograph assay
647339
Sus scrofa
?
-
-
-
?
Gelatin + H2O
zymograph assay
647339
Sus scrofa
?
-
-
-
?
additional information
recombinant zymogen can be activated by thermolysin
647339
Sus scrofa
?
-
-
-
-
additional information
enzyme participates in the degradation of enamel proteins in vivo
647339
Sus scrofa
?
-
-
-
-
polypeptide + H2O
-
647339
Sus scrofa
peptides
-
647339
Sus scrofa
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 28000, deglycosylated enzyme, SDS-PAGE; x * 34000-37000, glycosylated enzyme, 2 glycosylation forms, SDS-PAGE
Sus scrofa
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Sus scrofa
Other publictions for EC 3.4.21.B12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752370
Swedberg
Potent, selective, and cell-p ...
Homo sapiens
ACS Med. Chem. Lett.
9
1258-1262
2018
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752672
Perez
Direct evidence that KLK4 is ...
Homo sapiens
Biochem. Biophys. Res. Commun.
495
1896-1900
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
752888
Yang
Tissue kallikrein-related pep ...
Homo sapiens
Biol. Chem.
398
1151-1164
2017
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
753881
Wang
-
KLK4 is synchronically expres ...
Mus musculus
Int. J. Clin. Exp. Pathol.
10
5751-5757
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
754526
Vickers
Properties of the 4-kallikrei ...
Homo sapiens
J. Urol.
197
607-613
2017
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
754486
Fuhrman-Luck
Prostate cancer-associated ka ...
Homo sapiens
J. Proteome Res.
15
2466-2478
2016
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
731763
Lisle
Murine, but not human, ephrin- ...
Homo sapiens
Exp. Cell Res.
333
136-146
2015
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
3
-
-
4
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
3
-
-
4
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
731893
Mukai
Expression of human kallikrein ...
Homo sapiens
Hum. Cell
28
133-142
2015
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
3
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752500
Papagerakis
Clinical significance of kall ...
Homo sapiens
Anticancer Res.
35
1861-1866
2015
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
718348
Avgeris
Kallikrein-related peptidase 4 ...
Homo sapiens
Prostate
71
1780-1789
2011
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
717674
Wang
Kallikrein-related peptidase-4 ...
Homo sapiens
Int. J. Cancer
126
599-610
2010
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
693377
Tye
DPPI may activate KLK4 during ...
Homo sapiens
J. Dent. Res.
88
323-327
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680174
Westermann
New perspective on the tissue ...
Homo sapiens
Int. Immunopharmacol.
8
148-154
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687699
Ramsay
Kallikrein-related peptidase ( ...
Homo sapiens
J. Biol. Chem.
283
12293-12304
2008
1
1
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
4
-
1
3
-
2
-
-
-
2
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
4
-
1
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
691153
Debela
Structures and specificity of ...
Homo sapiens
Biol. Chem.
389
623-632
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
4
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691154
Lu
Functions of KLK4 and MMP-20 i ...
Homo sapiens
Biol. Chem.
389
695-700
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685946
Klokk
Kallikrein 4 is a proliferativ ...
Homo sapiens
Cancer Res.
67
5221-5230
2007
1
1
1
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686322
Davidson
Kallikrein 4 is expressed in m ...
Homo sapiens
Diagn. Cytopathol.
35
80-84
2007
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689848
Gao
Kallikrein 4 is a potential me ...
Homo sapiens
Prostate
67
348-360
2007
-
1
1
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664270
Beaufort
Interplay of human tissue kall ...
Homo sapiens
Biol. Chem.
387
217-222
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664273
Prezas
Overexpression of the human ti ...
Homo sapiens
Biol. Chem.
387
807-811
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667877
Obiezu
Human kallikrein 4: enzymatic ...
Homo sapiens
Biol. Chem.
387
749-759
2006
-
-
-
-
-
-
-
2
1
-
2
1
-
3
-
-
-
-
-
-
-
-
10
2
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
2
1
-
-
-
-
-
-
-
-
10
2
-
-
-
2
1
-
-
-
-
-
-
-
-
-
680680
Debela
Specificity profiling of seven ...
Homo sapiens
J. Biol. Chem.
281
25678-25688
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
2
-
-
3
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681390
Debela
Crystal structures of human ti ...
Homo sapiens
J. Mol. Biol.
362
1094-1107
2006
-
-
1
1
2
-
3
2
-
-
4
-
-
1
-
-
1
-
-
3
-
-
4
1
7
-
-
-
2
-
-
-
-
-
-
3
-
-
1
-
1
2
-
3
3
-
2
-
-
4
-
-
-
-
1
-
3
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
682813
Fernando
Porcine endometrial and concep ...
Sus scrofa
Reproduction
132
939-947
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686543
Wright
Human enamel phenotype associa ...
Homo sapiens
Eur. J. Oral Sci.
114 Suppl 1; 13-7
discussion 39-41, 379
2006
-
1
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686544
Yamakoshi
How do enamelysin and kallikre ...
Sus scrofa
Eur. J. Oral Sci.
114 Suppl 1; 45-51; discussion 93-5
379-80
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667120
Davidson
Kallikrein 4 expression is up- ...
Homo sapiens
Am. J. Clin. Pathol.
123
360-368
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668285
Obiezu
Human kallikrein 4: quantitati ...
Homo sapiens
Clin. Chem.
51
1432-1442
2005
-
2
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668144
Xi
Kallikrein 4 is a predominantl ...
Homo sapiens
Cancer Res.
64
2365-2370
2004
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669814
Hart
Mutation in kallikrein 4 cause ...
Homo sapiens
J. Med. Genet.
41
545-549
2004
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
395498
Boeckmann
The SWISS-PROT protein knowled ...
Homo sapiens
Nucleic Acids Res.
31
365-370
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647339
Ryu
Porcine kallikrein-4 activatio ...
Sus scrofa
Eur. J. Oral Sci.
110
358-365
2002
3
-
1
-
-
-
-
-
1
-
1
2
-
3
-
2
1
1
-
2
-
-
6
1
-
1
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
2
1
-
2
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
647332
Yousef
The new human tissue kallikrei ...
Homo sapiens
Endocr. Rev.
22
184-204
2001
2
1
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
4
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647338
Takayama
Characterization of hK4 (prost ...
Homo sapiens
Biochemistry
40
15341-15348
2001
-
-
1
-
-
-
4
-
-
-
1
4
-
1
-
1
1
-
1
1
4
-
24
1
1
1
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
1
4
-
-
1
1
1
1
4
-
24
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
647337
Hu
Characterization of the mouse ...
Homo sapiens, Mus musculus
Gene
251
1-8
2000
-
-
2
-
-
-
-
-
1
-
-
2
-
5
-
-
-
2
-
6
-
-
2
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647334
Yousef
Prostase/KLK-L1 is a new membe ...
Homo sapiens
Cancer Res.
59
4252-4256
1999
2
-
1
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
18
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
18
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647335
Stephenson
Localization of a new prostate ...
Homo sapiens
J. Biol. Chem.
274
23210-23214
1999
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647336
Nelson
Molecular cloning and characte ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
96
3114-3119
1999
-
-
1
-
-
-
-
-
1
-
-
1
-
3
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647333
Simmer
Purification, characterization ...
Sus scrofa, Sus scrofa EMSP1
J. Dent. Res.
77
377-386
1998
-
-
1
-
-
-
-
-
1
-
-
2
-
3
-
1
1
1
-
5
-
-
6
1
2
1
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
1
-
5
-
-
6
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-