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Literature summary for 3.4.21.B10 extracted from

  • Pampalakis, G.; Sykioti, V.; Ximerakis, M.; Stefanakou-Kalakou, I.; Melki, R.; Vekrellis, K.; Sotiropoulou, G.
    KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species (2017), Oncotarget, 8, 14502-14515 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B10

Application

Application Comment Organism
medicine possibility to exploit KLK6 as a novel therapeutic target for Parkinson disease and other synucleinopathies Homo sapiens

Protein Variants

Protein Variants Comment Organism
S197A inactive mutant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-synuclein + H2O Homo sapiens recombinant and naturally secreted KLK6 can readily cleave alpha-synuclein fibrils that have the potential for cell-to-cell propagation in a prion-like mechanism ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876
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-

Source Tissue

Source Tissue Comment Organism Textmining
cerebrospinal fluid in synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with alpha-synuclein in cerebrospinal fluid Homo sapiens
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nervous system
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 Homo sapiens
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SH-SY5Y cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-synuclein + H2O recombinant and naturally secreted KLK6 can readily cleave alpha-synuclein fibrils that have the potential for cell-to-cell propagation in a prion-like mechanism Homo sapiens ?
-
 ?
alpha-synuclein + H2O the enzyme cleaves human monomeric and mouse fibrilar alpha-synuclein, leading to the appearance of proteolytic peptide fragments below 15 kDa Homo sapiens ?
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 ?
latent transforming growth factor binding proteins 3 + H2O
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 Homo sapiens ?
-
 ?
latent transforming growth factor binding proteins 4 + H2O
-
 Homo sapiens ?
-
 ?
pro-ADAMTS19 + H2O KLK6 activates pro-ADAMTS19 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
KLK6
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 Homo sapiens

General Information

General Information Comment Organism
malfunction KLK6-deficient primary cortical neurons have increased ability for alpha-synuclein fibril uptake Homo sapiens
metabolism KLK6 can be a major player in the turnover of alpha-synuclein species Homo sapiens