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Literature summary for 3.4.21.B10 extracted from

  • Li, H.X.; Hwang, B.Y.; Laxmikanthan, G.; Blaber, S.I.
    Blaber, M.; Golubkov, P.A.; Ren, P.; Iverson, B.L.; Georgiou, G.: Substrate specificity of human kallikreins 1 and 6 determined by phage display (2008), Protein Sci., 17, 664-672.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B10

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.062
-
 WAAFRFSQA pH 7.5, 37°C Homo sapiens
0.069
-
 WYMTRSAMG pH 7.5, 37°C Homo sapiens
0.092
-
 WEAVRSAMW pH 7.5, 37°C Homo sapiens
0.182
-
 WIGFRNAGA pH 7.5, 37°C Homo sapiens
0.249
-
 WEAFRSSDQ pH 7.5, 37°C Homo sapiens
0.336
-
 WTAFRSAYG pH 7.5, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information KLK6 displays trypsin-like activity, with the P1 position occupied only by Arg and a strong preference for Ser in P1'. Increased frequency of Val or Phe at the P2 position, whereas Ala is strongly preferred at the P2' position. Cleaves peptides derived from human myelin protein and Abeta amyloid peptide Homo sapiens ?
-
 ?
WAAFRFSQA + H2O
-
 Homo sapiens WAAFR + FSQA
-
 ?
WEAFRSSDQ + H2O
-
 Homo sapiens WEAFR + SSDQ
-
 ?
WEAVRSAMW + H2O
-
 Homo sapiens WEAVR + SAMW
-
 ?
WIGFRNAGA + H2O
-
 Homo sapiens WIGFR + NAGA
-
 ?
WTAFRSAYG + H2O
-
 Homo sapiens WTAFR + SAYG
-
 ?
WYMTRSAMG + H2O
-
 Homo sapiens WYMTR + SAMG
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 6
-
 Homo sapiens
KLK6
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.9
-
 WAAFRFSQA pH 7.5, 37°C Homo sapiens
1.2
-
 WEAFRSSDQ pH 7.5, 37°C Homo sapiens
1.4
-
 WYMTRSAMG pH 7.5, 37°C Homo sapiens
1.7
-
 WIGFRNAGA pH 7.5, 37°C Homo sapiens
2
-
 WEAVRSAMW pH 7.5, 37°C Homo sapiens
3.8
-
 WTAFRSAYG pH 7.5, 37°C Homo sapiens