Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of protease M is increased in GST-pi-positive oligodendrocytes during remyelination. After tumor necrosis factor-alpha and IFN-gamma stimulation colocalization of protease M and myelin basic protein in the oligodendroglial process | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | protease M in oligodendrocytes is closely associated with the expression of the myelin basic protein and the PLP gene. Maintenance of myelination is an important function of protease M in oligodendrocytes. The enzyme may be related to the oligodendroglial response to myelin disorders | Mus musculus |
Cloned (Comment) | Organism |
---|---|
into pPUR-tRNA plasmid and transfected into primary oligodendrocytes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of protease M mRNA and protein is rapidly reduced in demyelination | Mus musculus | |
RNAi | suppression of protease M, causes a decrease in myelin basic protein mRNA in cultured oligodendrocytes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
oligodendrocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myelin basic protein + H2O | close relationship between protease M and myelin proteins | Mus musculus | ? | - |
? | |
myelin basic protein + H2O | close relationship between protease M and myelin proteins | Mus musculus BALB/c | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KLK6 | - |
Mus musculus |
protease M | - |
Mus musculus |