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Literature summary for 3.4.21.B1 extracted from

  • Kara, E.; Manna, D.; Loeset, G..; Schneider, E.L.; Craik, C.S; Kanse, S.
    Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates (2017), Thromb. Haemost., 117, 1750-1760 .
    View publication on PubMed
Search for more literature for 3.4.21.B1

Application

Application Comment Organism
analysis substrate Ala-Lys-Nle-Arg-7-amido-4-methylcoumarin can be used to measure FSAP activity in plasma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14520
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Lys-Nle-Arg-7-amido-4-methylcoumarin + H2O
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 Homo sapiens Ala-Lys-Nle-Arg + 7-amino-4-methylcoumarin
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 ?
additional information substrate Ala-Lys-Nle-Arg-7-amido-4-methylcoumarin is based on a representive FSAP-cleaved sequence obtained from positional scanning substrate combinatorial library method. The results show a predilection for cleavage at a cluster of basic amino acids on the nonprime side. Molecular modelling studies show a preference for Arg over Lys at the P1 site Homo sapiens ?
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 ?