Literature summary for 3.4.21.B1 extracted from

Byskov, K.; Boettger, T.; Ruehle, P.F.; Nielsen, N.V.; Etscheid, M.; Kanse, S.M.
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells (2017), Atherosclerosis, 265, 133-139 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14520	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	upon stimulation of vascular smooth muscle cells (VSMC) and endothelial cells (EC) with FSAP, pathways significantly activated by FSAP include those related to inflammation, apoptosis and cell growth in VSMC and inflammation in EC. The key upregulated genes in VSMC are AREG, PTGS2 and IL6, and in EC these are SELE, VCAM1, and IL8. Secretion of IL6 in VSMC and IL8 in EC is also stimulated by FSAP. Recombinant wild type protease domain of FSAP, but not the Marburg I-isoform, can recapitulate most of these effects. In VSMC, but not EC, gene expression by FSAP is impaired by PAR1 (protease-activated receptor1) receptor antagonists	Homo sapiens

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Release 2023.1 (January 2023)