Cloned (Comment) | Organism |
---|---|
expressed in Huh-7 cells | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | comparison of the cleavage efficiencies of all known HCV NS3-4A cleavage sequences in a cell-based system is reported. NS4B/NS5A and NS5A/NS5B are both processed efficiently in trans, in contrast to NS3/NS4A and NS4A/NS4B, which are not processed significantly above background. ER-anchoring of the substrate is critical for its cleavage by NS3-4A. Other HCV proteins or replicase components do not change NS3-4A substrate selectivity or activity | Hepacivirus C | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS3-4A protease | - |
Hepacivirus C |