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Literature summary for 3.4.21.98 extracted from

  • Ingallinella, P.; Bianchi, E.; Ingenito, R.; Koch, U.; Steinkühler, C.; Altamura, S.; Pessi, A.
    Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease (2000), Biochemistry, 39, 12898-12906.
    View publication on PubMed
Search for more literature for 3.4.21.98

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Asp-D-Glu-Leu-Ile-(beta-cyclohexylalanine)-Cys-(Me)Ala-Ser-His-Leu-NH2 IC50: 0.0006 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C
acetyl-Asp-Glu-(3,3-diphenylalanine)-Ile-(beta-cyclohexylalanine)-Cys-(Me)Ala-Ser-His-Leu-NH2 IC50: 0.0034 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C
acetyl-Glu-Asp-Val-Val-(alpha-aminobutyryl)-Cys-(1,2,3,4-tetrahydroisoquinoline-3-L-carboxyl)-Nle-Ser-Tyr-NH2 IC50: 0.0019 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C
acetyl-Glu-Asp-Val-Val-(alpha-aminobutyryl)-Cys-(Me)Ala-Nle-Ser-Tyr-NH2 IC50: 0.0035 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C
acetyl-Glu-Asp-Val-Val-Leu-Cys-(1,2,3,4-tetrahydroisoquinoline-3-L-carboxyl)-Nle-Ser-Tyr-NH2 IC50: 0.001 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Synonyms

Synonyms Comment Organism
NS3/4A protease
-
 Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
 IC50: 0.0006 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C acetyl-Asp-D-Glu-Leu-Ile-(beta-cyclohexylalanine)-Cys-(Me)Ala-Ser-His-Leu-NH2
0.001
-
 IC50: 0.001 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C acetyl-Glu-Asp-Val-Val-Leu-Cys-(1,2,3,4-tetrahydroisoquinoline-3-L-carboxyl)-Nle-Ser-Tyr-NH2
0.0019
-
 IC50: 0.0019 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C acetyl-Glu-Asp-Val-Val-(alpha-aminobutyryl)-Cys-(1,2,3,4-tetrahydroisoquinoline-3-L-carboxyl)-Nle-Ser-Tyr-NH2
0.0034
-
 IC50: 0.0034 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C acetyl-Asp-Glu-(3,3-diphenylalanine)-Ile-(beta-cyclohexylalanine)-Cys-(Me)Ala-Ser-His-Leu-NH2
0.0035
-
 IC50: 0.0035 mM, inhibitor is cleaved by NS3/4A protease Hepacivirus C acetyl-Glu-Asp-Val-Val-(alpha-aminobutyryl)-Cys-(Me)Ala-Nle-Ser-Tyr-NH2