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Literature summary for 3.4.21.93 extracted from

  • Duhamel, M.; Rodet, F.; Murgoci, A.N.; Desjardins, R.; Gagnon, H.; Wisztorski, M.; Fournier, I.; Day, R.; Salzet, M.
    The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways (2016), Sci. Rep., 6, 19360 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
NR-8383 cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function proprotein convertase PC1/3 regulates the endosomal toll-like receptor TLR9. Under CpG oligodesoxynucleotide challenge, PC1/3 traffics rapidly to colocalize with TLR9 in CpG oligodesoxynucleotide-containing endosomes with acidic pH. In PC1/3 knockdown macrophages, compartmentalization of TLR9 is altered and TLR9 clustered in multivesicular bodies. This clustering of TLR9 in multivesicular bodies dampens the anti-inflammatory STAT3 signalling pathway while it promotes the pro-inflammatory NF-kappaB pathway Mus musculus