Cloned (Comment) | Organism |
---|---|
- |
Trypanosoma brucei brucei |
Crystallization (Comment) | Organism |
---|---|
ligand-free open state and inhibitor-bound closed state crystal structures, to 2.4 and 2.85 A resolution, respectively. Peptides over 30 residues cannot fit the enzyme cavity, preventing the complete domain closure required for a key propeller Asp/Glu to fix the catalytic His and Arg in the catalytically competent conformation. This size exclusion mechanism protects larger peptides and proteins from degradation | Trypanosoma brucei brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei brucei | O76728 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
OPB | - |
Trypanosoma brucei brucei |