Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | inhibits PR3-induced kininogen reaction | Homo sapiens | |
anti-PR3 | partially inhibits PR3-induced kininogen reaction | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | neutrophil extracts from vasculitis patients and healthy controls contain comparable amounts of PR3 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | PR3 incubated with kininogen, or a synthetic peptide derived from kininogen, induces breakdown and release of a novel tridecapeptide termed PR3-kinin, NH2-MKRPPGFSPFRSS-COOH, consisting of bradykinin with two additional amino acids on each terminus. The reaction is specific. PR3-kinin binds to and activates human kinin B1 receptors, but does not bind to B2 receptors, expressed by transfected HEK293 cells in vitro. PR3-kinin is processed to bradykinin and des-Arg-bradykinin by plasma kallikrein. PR3 proteolyzes kininogen in a dose-dependent and specific manner. PR3 in neutrophil extracts induces kininogen proteolysis and induces release of bradykinin-like peptides from kininogen | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | neutrophil-derived PR3 can induce kallikrein-independent activation of the kinin pathway | Homo sapiens |