KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
hBMP-2 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
0.0001 | - |
pro-hTGF-beta2 protein | pH 7.0, 37°C | Homo sapiens | |
0.0001 | - |
pro-hTGF-best1 protein | pH 7.0, 37°C | Homo sapiens | |
0.00011 | - |
pro-MT-MMP 11 protein | pH 7.0, 37°C | Homo sapiens | |
0.00011 | - |
pro-MT-MMP 3 protein | pH 7.0, 37°C | Homo sapiens | |
0.00014 | - |
pro-hTGF-beta3 protein | pH 7.0, 37°C | Homo sapiens | |
0.00015 | - |
pro-MT-MMP 1 protein | pH 7.0, 37°C | Homo sapiens | |
0.0002 | - |
pro-hADAM-15 protein | pH 7.0, 37°C | Homo sapiens | |
0.00037 | - |
pro-MT-MMP 6 protein | pH 7.0, 37°C | Homo sapiens | |
0.0004 | - |
pro-hADAM-TS 6 protein | pH 7.0, 37°C | Homo sapiens | |
0.00045 | - |
pro-MT-MMP 4 protein | pH 7.0, 37°C | Homo sapiens | |
0.00055 | - |
pro-hADAM-TS 4 protein | pH 7.0, 37°C | Homo sapiens | |
0.00064 | - |
proaerolysin | pH 7.0, 37°C | Homo sapiens | |
0.0013 | - |
hBMP-2 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
0.0014 | - |
hBMP-4 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
0.0015 | - |
hBMP-4 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
0.00194 | - |
acetyl-RVRR-4-methylcoumarin 7-amide | pH 7.0, 37°C | Homo sapiens | |
0.0022 | - |
pro-hTGF-beta4 protein | pH 7.0, 37°C | Homo sapiens | |
0.0026 | - |
Shiga toxin | pH 7.0, 37°C | Homo sapiens | |
0.0067 | - |
pro-hADAMTS-23 protein | pH 7.0, 37°C | Homo sapiens | |
0.0091 | - |
pro-hADAMTS-17 protein | pH 7.0, 37°C | Homo sapiens | |
0.0118 | - |
Pseudomonas toxin | pH 7.0, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-GIRRKRSVSHQ-EDDnp + H2O | - |
Homo sapiens | Abz-GIRRKR + SVSHQ-EDDnp | - |
? | |
Abz-SGRSRRAIDLQEDDnp + H2O | - |
Homo sapiens | Abz-SGRSRR + AIDLQEDDnp | - |
? | |
Abz-SKRSRRSVSVQ-EDDnp + H2O | - |
Homo sapiens | Abz-SKRSRR + SVSVQ-EDDnp | - |
? | |
acetyl-RVRR-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | acetyl-RVRR + 7-amino-4-methylcoumarin | - |
? | |
hBMP-2 precursor protein + H2O | cleavage sites are HKREKR-/-QAKH and HVRISR-/-SLHQ | Homo sapiens | ? | - |
? | |
hBMP-4 precursor protein + H2O | cleavage sites are RRRAKR-/-SPKH and HVRISR-/-SLPQ | Homo sapiens | ? | - |
? | |
additional information | furin is a proprotein convertase that requires the cleavage sequence R-X-K/R-R, clear interdependence of furin subsites, substrate specificity with synthetic peptide substrates, overview | Homo sapiens | ? | - |
? | |
pro-hADAM-15 protein + H2O | cleavage site is HIRRRR-/-DVVT | Homo sapiens | ? | - |
? | |
pro-hADAM-TS 4 protein + H2O | cleavage site is RPRRAKR-/-FASL | Homo sapiens | ? | - |
? | |
pro-hADAM-TS 6 protein + H2O | cleavage site is HHRQRR-/-SVSI | Homo sapiens | ? | - |
? | |
pro-hADAMTS-17 protein + H2O | cleavage site is HVRKRR-/-ADPD | Homo sapiens | ? | - |
? | |
pro-hADAMTS-23 protein + H2O | cleavage site is LKRRKR-/-AVNP | Homo sapiens | ? | - |
? | |
pro-hTGF-best1 protein + H2O | - |
Homo sapiens | ? | - |
? | |
pro-hTGF-beta1 protein + H2O | cleavage site is NRRKKR-/-ALDA | Homo sapiens | ? | - |
? | |
pro-hTGF-beta2 protein + H2O | cleavage site is GQRKKR-/-ALDT | Homo sapiens | ? | - |
? | |
pro-hTGF-beta3 protein + H2O | cleavage site is SSRHRR-/-ALDT | Homo sapiens | ? | - |
? | |
pro-hTGF-beta4 protein + H2O | cleavage site is RSRGRR-/-FSQS | Homo sapiens | ? | - |
? | |
pro-MT-MMP 1 protein + H2O | cleavage site is NVRRKR-/-YALT | Homo sapiens | ? | - |
? | |
pro-MT-MMP 11 protein + H2O | cleavage site is RHRQKR-/-FVLS | Homo sapiens | ? | - |
? | |
pro-MT-MMP 3 protein + H2O | cleavage site is RNRQKR-/-FVLS | Homo sapiens | ? | - |
? | |
pro-MT-MMP 4 protein + H2O | cleavage site is QSRRRR-/-QTPP | Homo sapiens | ? | - |
? | |
pro-MT-MMP 6 protein + H2O | cleavage site is VRRRRR-/-YALS | Homo sapiens | ? | - |
? | |
proaerolysin + H2O | cleavage site is KVRRAR-/-SVDG | Homo sapiens | ? | - |
? | |
Pseudomonas toxin + H2O | cleavage site is RHRQPR-/-GWEQ | Homo sapiens | ? | - |
? | |
Shiga toxin + H2O | cleavage site is ASRVAR-/-MASD | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | furin belongs to MEROPS clan SB, family S8 | Homo sapiens |
Proprotein convertase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
pro-MT-MMP 3 protein | pH 7.0, 37°C | Homo sapiens | |
0.54 | - |
Pseudomonas toxin | pH 7.0, 37°C | Homo sapiens | |
0.7 | - |
acetyl-RVRR-4-methylcoumarin 7-amide | pH 7.0, 37°C | Homo sapiens | |
0.84 | - |
pro-MT-MMP 6 protein | pH 7.0, 37°C | Homo sapiens | |
1 | - |
pro-hADAMTS-23 protein | pH 7.0, 37°C | Homo sapiens | |
1 | - |
pro-hADAMTS-17 protein | pH 7.0, 37°C | Homo sapiens | |
1.2 | - |
pro-hTGF-beta4 protein | pH 7.0, 37°C | Homo sapiens | |
1.3 | - |
pro-MT-MMP 11 protein | pH 7.0, 37°C | Homo sapiens | |
1.5 | - |
pro-hTGF-beta1 protein | pH 7.0, 37°C | Homo sapiens | |
2.4 | - |
pro-MT-MMP 1 protein | pH 7.0, 37°C | Homo sapiens | |
3 | - |
hBMP-2 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
3.4 | - |
pro-hTGF-beta2 protein | pH 7.0, 37°C | Homo sapiens | |
3.6 | - |
hBMP-2 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
3.6 | - |
hBMP-4 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
4.5 | - |
pro-hADAM-TS 4 protein | pH 7.0, 37°C | Homo sapiens | |
5.5 | - |
pro-hADAM-15 protein | pH 7.0, 37°C | Homo sapiens | |
5.5 | - |
pro-MT-MMP 4 protein | pH 7.0, 37°C | Homo sapiens | |
5.6 | - |
hBMP-4 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
8.4 | - |
pro-hTGF-beta3 protein | pH 7.0, 37°C | Homo sapiens | |
12.2 | - |
proaerolysin | pH 7.0, 37°C | Homo sapiens | |
16 | - |
Shiga toxin | pH 7.0, 37°C | Homo sapiens | |
40 | - |
pro-hADAM-TS 6 protein | pH 7.0, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.5 | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pH-profiles of furin activity in the presence and absence of salts, e.g. KCl. The pK1 values for the pH-profiles of hydrolysis of all four substrates in the presence of KCl are lower than those in its absence | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
45 | - |
Pseudomonas toxin | pH 7.0, 37°C | Homo sapiens | |
109 | - |
pro-hADAMTS-17 protein | pH 7.0, 37°C | Homo sapiens | |
143 | - |
pro-hADAMTS-23 protein | pH 7.0, 37°C | Homo sapiens | |
361 | - |
acetyl-RVRR-4-methylcoumarin 7-amide | pH 7.0, 37°C | Homo sapiens | |
534 | - |
pro-hTGF-beta4 protein | pH 7.0, 37°C | Homo sapiens | |
2240 | - |
pro-MT-MMP 6 protein | pH 7.0, 37°C | Homo sapiens | |
2331 | - |
hBMP-2 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
2649 | - |
hBMP-4 precursor protein | second cleavage site, pH 7.0, 37°C | Homo sapiens | |
3700 | - |
hBMP-4 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
4545 | - |
pro-MT-MMP 3 protein | pH 7.0, 37°C | Homo sapiens | |
6134 | - |
Shiga toxin | pH 7.0, 37°C | Homo sapiens | |
8127 | - |
pro-hADAM-TS 4 protein | pH 7.0, 37°C | Homo sapiens | |
11450 | - |
pro-MT-MMP 11 protein | pH 7.0, 37°C | Homo sapiens | |
12670 | - |
pro-MT-MMP 4 protein | pH 7.0, 37°C | Homo sapiens | |
14700 | - |
pro-hTGF-beta1 protein | pH 7.0, 37°C | Homo sapiens | |
15800 | - |
pro-MT-MMP 1 protein | pH 7.0, 37°C | Homo sapiens | |
20670 | - |
proaerolysin | pH 7.0, 37°C | Homo sapiens | |
27600 | - |
pro-hADAM-15 protein | pH 7.0, 37°C | Homo sapiens | |
34200 | - |
pro-hTGF-beta2 protein | pH 7.0, 37°C | Homo sapiens | |
50710 | - |
hBMP-2 precursor protein | first cleavage site, pH 7.0, 37°C | Homo sapiens | |
60140 | - |
pro-hTGF-beta3 protein | pH 7.0, 37°C | Homo sapiens | |
100000 | - |
pro-hADAM-TS 6 protein | pH 7.0, 37°C | Homo sapiens |