Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | furin is up-regulated by iron deficiency and hypoxia in association with the stabilization of HIF-1alpha | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
R335Q | cleavage mutant, soluble hemojuvelin is reduced | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | soluble hemojuvelin is reduced in cells treated with a furin inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | soluble hemojuvelin originates from a furin cleavage at position 332-335. Soluble hemojuvelin is increased in cells overexpressing exogenous furin | Mus musculus | ? | - |
? |