Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | L-Sox5 and Sox-6 act as negative regulators of Sox9-induced furin expression | Homo sapiens | |
additional information | relationship between Sox-9 dependent expression of furin and the maturation/bioactivation of substrates involved in chondrogenesis. Peak expression of both furin mRNA and furin parathyroid hormone-related peptide maturation in ATDC5 cells during chondrocyte nodule formation stage | Mus musculus |
Application | Comment | Organism |
---|---|---|
additional information | Sox-9 regulates furin during chondrogenesis | Mus musculus |
additional information | Sox-9 regulates furin during chondrogenesis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HepG2 cells transiently transfected with furin luciferase reporter constructs pGL2-P1, pGL2-P1A and pGL2-P1B | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | point mutations of sites A, B and C of furin P1A promoter. Mutations of site A and more importantly site B decreases Sox9-induced promoter activity, while mutations of both A and B sites result in only slight but nonsignificant additional inhibition. Mutation of site C does not reduce Sox9 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
decanoyl-Arg-Val-Lys-Arg-chloromethylketone | blocks furin activity, 99% inhibition of parathyroid hormone-related peptide maturation | Mus musculus | |
hexa-D-arginine | blocks furin activity, 85% inhibition of parathyroid hormone-related peptide maturation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | ATDC5 cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
parathyroid hormone-related peptide + H2O | - |
Mus musculus | ? | - |
? | |
TACE/ADAM17 + H2O | - |
Mus musculus | ? | - |
? | |
TGFbeta1 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Proprotein convertase | - |
Mus musculus |
Proprotein convertase | - |
Homo sapiens |