Application | Comment | Organism |
---|---|---|
medicine | potential therapeutic value of furin inhibitors, alpha1-PDX is able to block in vivo maturation of pro-gB, the cytomegalovirus envelope glycoprotein | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA cloning | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 | - |
Mus musculus | |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Leu-NH2 | - |
Mus musculus | |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Arg-NH2 | - |
Mus musculus | |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Leu-NH2 | - |
Mus musculus | |
Ac-HHKRRR-NH2 | - |
Mus musculus | |
Ac-HRKRRR-NH2 | - |
Mus musculus | |
Ac-KHKRRR-NH2 | - |
Mus musculus | |
Ac-KRKRRR-NH2 | - |
Mus musculus | |
Ac-LLRVKR | - |
Mus musculus | |
Ac-LLRVKR-NH2 | - |
Mus musculus | |
Ac-MHKRRR-NH2 | - |
Mus musculus | |
Ac-MRKRRR-NH2 | - |
Mus musculus | |
Ac-RHKRRR-NH2 | - |
Mus musculus | |
Ac-RRKRRR-NH2 | - |
Mus musculus | |
alpha1-PDX | - |
Homo sapiens | |
hepta-L-arginine | - |
Mus musculus | |
hexa-D-arginine | - |
Mus musculus | |
hexa-L-arginine | - |
Mus musculus | |
LLRVKR | - |
Mus musculus | |
LLRVKR-NH2 | - |
Mus musculus | |
nona-L-arginine | most potent inhibitor | Mus musculus | |
octa-L-arginine | - |
Mus musculus | |
penta-L-arginine | - |
Mus musculus | |
tetra-L-arginine | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | trans Golgi network | Mus musculus | 5794 | - |
Golgi apparatus | trans Golgi network | Homo sapiens | 5794 | - |
membrane | membrane-bound | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
59000 | - |
gel filtration | Mus musculus |
61000 | - |
Western blotting with anti-furin antiserum MON148 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
recombinant furin | Mus musculus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.35 | - |
recombinant furin | Mus musculus |
Storage Stability | Organism |
---|---|
-80°C, 10% glycerol, no detectable loss of activity over 6 months | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
nona-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.000042 | - |
nona-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.000061 | - |
octa-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.000068 | - |
hepta-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.000106 | - |
hexa-D-arginine | pH 7.0, 37°C | Mus musculus | |
0.000114 | - |
tetra-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.00042 | - |
LLRVKR | pH 7.0, 37°C | Mus musculus | |
0.0008 | - |
LLRVKR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.00099 | - |
penta-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.0013 | - |
Ac-RRKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0016 | - |
Ac-KRKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0021 | - |
Ac-HRKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0023 | - |
Ac-MRKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0024 | - |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0034 | - |
LLRVKR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0034 | - |
Ac-RHKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0035 | - |
AcLLRVKR | pH 7.0, 37°C | Mus musculus | |
0.0052 | - |
Ac-KHKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0053 | - |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Leu-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0064 | - |
tetra-L-arginine | pH 7.0, 37°C | Mus musculus | |
0.007 | - |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Arg-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0103 | - |
Ac-HHKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0132 | - |
Ac-MHKRRR-NH2 | pH 7.0, 37°C | Mus musculus | |
0.0227 | - |
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Leu-NH2 | pH 7.0, 37°C | Mus musculus |