Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | from bovine | Crotalus atrox | |
additional information | no inhibition by EDTA, 2-mercaptoethanol | Crotalus atrox | |
PMSF | - |
Crotalus atrox | |
Soybean trypsin inhibitor | - |
Crotalus atrox |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Crotalus atrox | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no metalloproteinase | Crotalus atrox | |
additional information | no activation by Ca2+ | Crotalus atrox |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
N-terminal sequence | Crotalus atrox |
30000 | 35000 | Crotalus atrox, gel filtration | Crotalus atrox |
33000 | - |
1 * 33000, Crotalus atrox, isozymes A1 and A3, SDS-PAGE | Crotalus atrox |
35000 | - |
1 * 35000, Crotalus atrox, isozyme A2, SDS-PAGE | Crotalus atrox |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrinogen + H2O | Crotalus atrox | three of numerous fibrinogenases of Crotalus atrox venom | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | - |
Western diamondback rattlesnake | - |
Purification (Comment) | Organism |
---|---|
multiple isoforms | Crotalus atrox |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrinogen + H2O | three of numerous fibrinogenases of Crotalus atrox venom | Crotalus atrox | ? | - |
? | |
Fibrinogen Aalpha-chains + H2O | - |
Crotalus atrox | ? | - |
? | |
fibrinogen B-beta-chain + H2O | - |
Crotalus atrox | ? | - |
? | |
additional information | fibrinogen gamma-chain | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | cleavage sites: Tyr16-Leu17 (isozymes A1-3), Gly23-Phe24, Phe25-Val26 (isozymes A1 and 2), His5-Leu6 (isozyme A1), His10-Leu11, Leu15-Tyr16, Phe24-Phe25 (isozyme A2) | Crotalus atrox | Hydrolyzed insulin B-chain | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 33000, Crotalus atrox, isozymes A1 and A3, SDS-PAGE | Crotalus atrox |
monomer | 1 * 35000, Crotalus atrox, isozyme A2, SDS-PAGE | Crotalus atrox |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Crotalus atrox |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
75 | - |
30 min, stable, isozyme A3 | Crotalus atrox |
85 | - |
30 min, stable, isozymes A1 and 2 | Crotalus atrox |