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Literature summary for 3.4.21.7 extracted from

  • Castiblanco-Valencia, M.M.; Fraga, T.R.; Pagotto, A.H.; Serrano, S.M.; Abreu, P.A.; Barbosa, A.S.; Isaac, L.
    Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins A new role of LigA and LigB in invasion and complement immune evasion (2016), Immunobiology, 221, 679-689 .
    View publication on PubMed
Search for more literature for 3.4.21.7

Activating Compound

Activating Compound Comment Organism Structure
urokinase-type plasminogen activator plasminogen bound to immunoglobulin-like proteins LigA and LigB is converted to proteolytic active plasmin in the presence of urokinase-type plasminogen activator Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Homo sapiens cleavage by plasmin produces bands of 46000 Da, 40000 Da, 30000 Da and 17000 Da ?
-
 ?
complement component C5 + H2O Homo sapiens cleavage by plasmin produces bands of approximately 41000 Da and 30000-28000 Da ?
-
 ?
Fibrinogen + H2O Homo sapiens the fibrinogen alpha-chain is degraded in low-molecular-mass fragments of approximately 63000-60000 Da ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O cleavage by plasmin produces bands of 46000 Da, 40000 Da, 30000 Da and 17000 Da Homo sapiens ?
-
 ?
complement component C5 + H2O cleavage by plasmin produces bands of approximately 41000 Da and 30000-28000 Da Homo sapiens ?
-
 ?
D-Val-Leu-Lys-4-nitroanilide + H2O
-
 Homo sapiens D-Val-Leu-Lys + 4-nitroaniline
-
 ?
Fibrinogen + H2O the fibrinogen alpha-chain is degraded in low-molecular-mass fragments of approximately 63000-60000 Da Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
plasminogen
-
 Homo sapiens
PLG
-
 Homo sapiens