Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tissue plasminogen activator | - |
Homo sapiens | |
urokinase plasminogen activator | - |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with trans-4-aminomethylcyclohexanecarbonyl-L-tyrosine-n-octylamide, using 10% (w/v) polyethylene glycol 6000, 4% (v/v) 2-methyl-2,4-pentanediol, and 0.1 M MES (pH 5.0) at 20°C | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F587A | binding site mutant | Homo sapiens |
F587A/K607A | binding site mutant | Homo sapiens |
K607A | binding site mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-lysine | - |
Homo sapiens | |
additional information | L-methionine and L-alanine show minimal reductions of enzyme activity, even at 125 mM | Homo sapiens | |
PSI-112 | - |
Homo sapiens | |
Tranexamic acid | - |
Homo sapiens | |
trans-4-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-N-octylamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Plm | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00017 | - |
mutant enzyme K607A, pH and temperature not specified in the publication | Homo sapiens | trans-4-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-N-octylamide | |
0.00024 | - |
wild type enzyme, pH and temperature not specified in the publication | Homo sapiens | trans-4-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-N-octylamide | |
0.00037 | - |
mutant enzyme K607A, pH and temperature not specified in the publication | Homo sapiens | PSI-112 | |
0.00038 | - |
wild type enzyme, pH and temperature not specified in the publication | Homo sapiens | PSI-112 | |
0.0011 | - |
mutant enzyme F587A/K607A, pH and temperature not specified in the publication | Homo sapiens | trans-4-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-N-octylamide | |
0.00115 | - |
mutant enzyme F587A, pH and temperature not specified in the publication | Homo sapiens | trans-4-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-N-octylamide | |
0.00148 | - |
mutant enzyme F587A, pH and temperature not specified in the publication | Homo sapiens | PSI-112 | |
0.00175 | - |
mutant enzyme F587A/K607A, pH and temperature not specified in the publication | Homo sapiens | PSI-112 | |
0.08679 | - |
wild type enzyme, pH and temperature not specified in the publication | Homo sapiens | Tranexamic acid |