Application | Comment | Organism |
---|---|---|
medicine | antifibrinolytic inhibitors, e.g. aprotinin, of the serine protease plasmin are commonly used to reduce bleeding during surgery | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens | |
Lys-Met(sulfone)-Tyr-Arg | shows 25fold selectivity for plasmin over plasma kallikrein | Homo sapiens | |
additional information | development and evaluation of alternative potent and selective serine lysine analogues to inhibit plasmin, usage of a noncombinatorial peptide library to define plasmin's extended substrate specificity and guide the design of potent transition state analogue inhibitors, molecular modeling, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | plasmin shows substrate binding site cooperativity, | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-FM(O2)YK-4-nitroanilide + H2O | peptide substrate, M(O2) i.e. L-methionine sulfone | Homo sapiens | Ac-FM(O2)YK + 4-nitroaniline | M(O2) i.e. L-methionine sulfone | ? | |
Ac-KM(O2)FR-4-nitroanilide + H2O | peptide substrate, M(O2) i.e. L-methionine sulfone | Homo sapiens | Ac-KM(O2)FR + 4-nitroaniline | M(O2) i.e. L-methionine sulfone | ? | |
Ac-KM(O2)YR-4-nitroanilide + H2O | peptide substrate, M(O2) i.e. L-methionine sulfone | Homo sapiens | Ac-KM(O2)YR + 4-nitroaniline | M(O2) i.e. L-methionine sulfone | ? | |
Ac-RM(O2)WR-4-nitroanilide + H2O | peptide substrate, M(O2) i.e. L-methionine sulfone | Homo sapiens | Ac-RM(O2)WR + 4-nitroaniline | M(O2) i.e. L-methionine sulfone | ? | |
Ac-RM(O2)YR-4-nitroanilide + H2O | peptide substrate, M(O2) i.e. L-methionine sulfone | Homo sapiens | Ac-RM(O2)YR + 4-nitroaniline | M(O2) i.e. L-methionine sulfone | ? | |
Fibrin + H2O | fibrin is formed from fibrinogen by thrombin, EC 3.4.21.5 | Homo sapiens | ? | - |
? | |
KQWK-4-nitroanilide + H2O | peptide substrate | Homo sapiens | KQWK + 4-nitroaniline | - |
? | |
KTFK-4-nitroanilide + H2O | peptide substrate | Homo sapiens | KTFK + 4-nitroaniline | - |
? | |
additional information | plasmin, possessing various substrate binding sites, shows substrate binding site cooperativity, molecular modeling of the plasmin-Ac-RM(O2)YR-H complex | Homo sapiens | ? | - |
? | |
RQFR-4-nitroanilide + H2O | peptide substrate | Homo sapiens | RQFR + 4-nitroaniline | - |
? | |
RQWK-4-nitroanilide + H2O | peptide substrate | Homo sapiens | RQWK + 4-nitroaniline | - |
? | |
VQYK-4-nitroanilide + H2O | peptide substrate | Homo sapiens | VQYK + 4-nitroaniline | - |
? | |
VQYR-4-nitroanilide + H2O | peptide substrate | Homo sapiens | VQYR + 4-nitroaniline | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | 37 | assay at 37°C or at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 8 | assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000031 | - |
Lys-Met(sulfone)-Tyr-Arg | pH 8.0, 22°C | Homo sapiens |