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Literature summary for 3.4.21.7 extracted from

  • Zhang, Y.; Zhou, Z.H.; Bugge, T.H.; Wahl, L.M.
    Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin (2007), J. Immunol., 179, 3297-3304.
    View publication on PubMed
Search for more literature for 3.4.21.7

Activating Compound

Activating Compound Comment Organism Structure
high molecular weight urokinase-type plasminogen activator induces a significant increase in plasmin activity in unstimulated or lipopolysaccharide-stimulated monocytes Homo sapiens
low molecular weight urokinase-type plasminogen activator induces a significant increase in plasmin activity in unstimulated or lipopolysaccharide-stimulated monocytes Homo sapiens
additional information ATF-urokinase-type plasminogen activator causes little, if any, increase in plasmin activity in unstimulated or lipopolysaccharide-stimulated monocytes Homo sapiens

Application

Application Comment Organism
medicine binding of inactive plasmin to annexin A2 inhibits plasmin induction of matrix metalloproteinase-1. Inactive plasmin may be useful in suppressing inflammatory diseases that involve a series of proteases (e.g., matrix metalloproteinases) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inactive plasmin, in which the catalytic site has been irreversibly blocked with a peptide inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
annexin A2 + H2O interaction of plasmin with annexin A2 results in the stimulation of ERK1/2 and p38 MAPK, cyclooxygenase-2, and PGE(2), leading to increased matrix metalloproteinase-1 production Homo sapiens ?
-
 ?
H-D-norleucyl-hexahydrotyrosol-lysine-para nitroanilide diacetate + H2O
-
 Homo sapiens ?
-
 ?