Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipid | vesicles of 20% phosphatidylserine, 40% phosphatidylcholine, and 40% phosphatidylethanolamine | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | proteolysis at Arg336 occurs 25-fold faster than at Arg562. Replacing residues flanking Arg336 en bloc with the corresponding residues surrounding Arg562 markedly reduces the rate of cleavage at Arg336 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | Homo sapiens | inactivation through cleavage at Arg306, Arg506, and Arg679 | ? | - |
? | |
Factor VIIIa + H2O | Homo sapiens | inactivation through cleavages at Arg336 in the A1 subunit and Arg562 in the A2 subunit | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | inactivation through cleavage at Arg306, Arg506, and Arg679 | Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | inactivation through cleavages at Arg336 in the A1 subunit and Arg562 in the A2 subunit | Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | inactivation through cleavages at Arg336 in the A1 subunit and Arg562 in the A2 subunit. Proteolysis at Arg336 occurs 25fold faster than at Arg562. Activities with substrate mutants, overview. The inactivation rates observed for point mutations at the P3 and P2 positions, Gln334Asp, Leu335Gln, and Leu335Arg, are reduced by about 2fold compared with wild-type factor VIIIa | Homo sapiens | ? | - |
? | |
L-pGln-L-Pro-L-Arg-4-nitroanilide + H2O | - |
Homo sapiens | L-pGln-L-Pro-L-Arg + 4-nitroaniline | - |
? | |
additional information | P4-P3' residues flanking cleavage sites in factors VIIIa and Va, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | residues Arg336 and Arg562 are involved in the catalytic mechanism | Homo sapiens |