Cloned (Comment) | Organism |
---|---|
expression in AV12-664 cells, activation with rat thrombomodulin/bovine thrombin complex | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the protein C pathway plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased organ damage and dysfunction, and mortality, cecal ligation and puncture model, overview, activated protein C acts as feedback inhibitor of thrombin production and has receptor-mediated anti-inflammatory and cytoprotective effects, treatment with activated protein C results in suppression of cytokine response and improved organ function | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | in thrombotic stress, the protein C zymogen is converted to its active form by thrombin in complex with endothelial surface thrombomodulin | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the protein C pathway plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased organ damage and dysfunction, and mortality, cecal ligation and puncture model, overview, activated protein C acts as feedback inhibitor of thrombin production and has receptor-mediated anti-inflammatory and cytoprotective effects, treatment with activated protein C results in suppression of cytokine response and improved organ function | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Rattus norvegicus |