Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-antiplasmin | alpha-PL | Mus musculus | |
epsilon-aminocaproic acid | EACA | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? | |
plasminogen + H2O | Mus musculus CD-1 | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P11214 | - |
- |
Mus musculus CD-1 | P11214 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Mus musculus | - |
ovarian cumulus cell | - |
Mus musculus | - |
spermatozoon | - |
Mus musculus | - |
zona pellucida | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
plasminogen + H2O | - |
Mus musculus CD-1 | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLAT | - |
Mus musculus |
Tissue plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | the plasminogen-plasmin (PLG-PLA) system plays a role in thrombolysis, being capable of degrading blood clots. THe system consists of plasminogen, the inactive zymogen produced principally in the liver, its activators (tissue plasminogen activator, tPA and uroquinase plasminogen activator, uPA (EC 3.4.21.73)), their inhibitors (belonging to the serpin gene superfamily, named PAI-1, PAI-2, PAI-3 and protease nexin I), the uPA receptor and, finally, the active enzyme plasmin and its inhibitor, alpha-antiplasmin (alpha-PL). Apart from its fibrinolytic function, the PLG-PLA system is important in degrading the extracellular matrix in multiple tissues contributing to cell migration, angiogenesis, tissue repair and remodelling or tumour invasion | Mus musculus |
additional information | tPA is active in solution | Mus musculus |
physiological function | tissue plasminogen activator (tPA) of paternal origin is necessary for the success of in vitro but not of in vivo fertilisation in the mouse. The presence of exogenous plasminogen drastically reduces the fertilisation rate under in vitro conditions. When plasminogen is present in combination with inhibitors (e.g. alpha-PL or EACA), the fertilisation rate is partially restored | Mus musculus |