Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme-mediated degradation of NR2B is plasmin-independent | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of cleavage of the N-methyl-D-aspartate receptor NR2B domain by alpha2-antiplasmin, but by a commercial tissue plasminogen activator inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme can be released into the extracellular space upon depolarizing stimulation | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | activation | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00750 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
hypothalamus | - |
Homo sapiens | - |
microglia | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine-p-nitroanilide + H2O | a chromogenic substrate | Homo sapiens | methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine + p-nitroaniline | - |
? | |
N-methyl-D-aspartate receptor + H2O | usage of total rat brain lysates or MBP-ATD2B fusion proteins, the recombinant human enzyme shows cleavage of the ATD sequence in the NR2B subunit N-terminus of N-methyl-D-aspartate (NMDA) receptor. Enzyme-mediated degradation of NR2B is plasmin-independent. The enzyme cleaves the MBP-ATD2B fusion protein | Homo sapiens | ? | an Arg27-Arg67-truncated NR2B-containing NMDA receptor might be formed | ? | |
plasminogen + H2O | activation | Homo sapiens | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Homo sapiens |
tPA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme may directly interact with NR2B subunits of N-methyl-D-aspartate receptors leading to a change in pharmacological properties of NR2B-containing NMDA receptors | Homo sapiens |