Literature summary for 3.4.21.6 extracted from

Ilin, I.; Lipets, E.; Sulimov, A.; Kutov, D.; Shikhaliev, K.; Potapov, A.; Krysin, M.; Zubkov, F.; Sapronova, L.; Ataullakhanov, F.; Sulimov, V.
New factor Xa inhibitors based on 1,2,3,4-tetrahydroquinoline developed by molecular modelling (2019), J. Mol. Graph. Model., 89, 215-224 .

Inhibitors

Inhibitors	Comment	Organism
2,2,4,7-tetramethyl-6-[2-(4-methylphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-1,2,3,4-tetrahydroquinoline	89% activity at 0.03 mM	Homo sapiens
6-[2-(4-chlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline	16% activity at 0.005 mM; 35% activity at 0.03 mM; 63% activity at 0.001 mM; 67% activity at 0.03 mM; 76% activity at 0.005 mM; 82% activity at 0.03 mM; 85% activity at 0.005 mM; 87% activity at 0.03 mM; 8% activity at 0.005 mM; 94% activity at 0.03 mM	Homo sapiens
additional information	not inhibited by VGY-000058	Homo sapiens
N-(2,4-dichlorophenyl)-4-(2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)pyrimidin-2-amine	1% activity at 0.03 mM	Homo sapiens
rivaroxaban	-	Homo sapiens
VGY-000010	-	Homo sapiens
VGY-000014	-	Homo sapiens
VGY-000046	-	Homo sapiens
VGY-000049	-	Homo sapiens
VGY-000060	-	Homo sapiens
VGY-000063	-	Homo sapiens
VGY-000073	-	Homo sapiens
VGY-0006201	-	Homo sapiens
VGY-0006208	-	Homo sapiens
VGY-0006212	-	Homo sapiens
VGY-0224586	-	Homo sapiens
VGY-0224865	-	Homo sapiens
VGY-0224867	-	Homo sapiens
VGY-0224887	-	Homo sapiens
VGY-0224908	-	Homo sapiens
VGY-0224909	-	Homo sapiens
VGY-0224918	-	Homo sapiens
VGY-0224933	-	Homo sapiens
VGY-0224945	-	Homo sapiens
VGY-0224950	-	Homo sapiens
VGY-0224963	-	Homo sapiens
VGY-0224989	-	Homo sapiens
VGY-0225108	-	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P00742	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-D-Arg-Gly-Arg-4-nitroanilide + H2O	i.e S2765	Homo sapiens	Z-D-Arg-Gly-Arg + 4-nitroaniline	-	?

Synonyms	Comment	Organism
FXa	-	Homo sapiens