BRENDA - Enzyme Database
show all sequences of 3.4.21.47

Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement

Rawal, N.; Rajagopalan, R.; Salvi, V.P.; J. Biol. Chem. 283, 7853-7863 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
complement activation via the lectin pathway on zymosan particles is at least 4times more efficient than via the classical pathway on sheep erythrocytes coated with antibody. Every C4b deposited via the lectin pathway is capable of forming a convertase in contrast to only one of four C4b molecules deposited via the classical pathway. Rate of formation of lectin pathway C3/C5 convertases depends on the activation of C4 and C2 by MASP-2
Homo sapiens
Application
Application
Commentary
Organism
medicine
activation of complement via the lectin pathway may be a more prominent contributor to the pathology of inflammatory reactions as compared to activation of complement via the classical pathway
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0000075
-
complement component C5
high-affinity C5 convertase (EMan,C3bC4b,C2a)
Homo sapiens
0.0000086
-
complement component C5
high-affinity C5 convertase (ZymM1,C3bC4b,C2a)
Homo sapiens
0.00273
-
complement component C5
surface-bound C3/C5 convertase (ZymM1,C4b,C2a)
Homo sapiens
0.0688
-
complement component C5
surface-bound C3/C5 convertase (EMan,M1,C4b,C2a)
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
complement proteins purified by gel filtration, to homogeneity
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
complement component C5 + H2O
-
698871
Homo sapiens
complement component C5a + complement component C5b
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
C3/C5 convertase
-
Homo sapiens
C5 convertase
-
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0082
-
complement component C5
surface-bound C3/C5 convertase (EMan,M1,C4b,C2a)
Homo sapiens
0.011
-
complement component C5
surface-bound C3/C5 convertase (ZymM1,C4b,C2a)
Homo sapiens
0.013
-
complement component C5
high-affinity C5 convertase (ZymM1,C3bC4b,C2a)
Homo sapiens
0.026
-
complement component C5
high-affinity C5 convertase (EMan,C3bC4b,C2a)
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
complement activation via the lectin pathway on zymosan particles is at least 4times more efficient than via the classical pathway on sheep erythrocytes coated with antibody. Every C4b deposited via the lectin pathway is capable of forming a convertase in contrast to only one of four C4b molecules deposited via the classical pathway. Rate of formation of lectin pathway C3/C5 convertases depends on the activation of C4 and C2 by MASP-2
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
activation of complement via the lectin pathway may be a more prominent contributor to the pathology of inflammatory reactions as compared to activation of complement via the classical pathway
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0000075
-
complement component C5
high-affinity C5 convertase (EMan,C3bC4b,C2a)
Homo sapiens
0.0000086
-
complement component C5
high-affinity C5 convertase (ZymM1,C3bC4b,C2a)
Homo sapiens
0.00273
-
complement component C5
surface-bound C3/C5 convertase (ZymM1,C4b,C2a)
Homo sapiens
0.0688
-
complement component C5
surface-bound C3/C5 convertase (EMan,M1,C4b,C2a)
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
complement proteins purified by gel filtration, to homogeneity
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
complement component C5 + H2O
-
698871
Homo sapiens
complement component C5a + complement component C5b
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0082
-
complement component C5
surface-bound C3/C5 convertase (EMan,M1,C4b,C2a)
Homo sapiens
0.011
-
complement component C5
surface-bound C3/C5 convertase (ZymM1,C4b,C2a)
Homo sapiens
0.013
-
complement component C5
high-affinity C5 convertase (ZymM1,C3bC4b,C2a)
Homo sapiens
0.026
-
complement component C5
high-affinity C5 convertase (EMan,C3bC4b,C2a)
Homo sapiens
Other publictions for EC 3.4.21.47
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752433
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Am. J. Kidney Dis.
74
224-238
2019
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1
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1
1
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753422
Heesterbeek
Bacterial killing by compleme ...
Homo sapiens
EMBO J.
38
e99852
2019
-
-
1
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1
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1
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4
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1
1
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754745
Fridkis-Hareli
The human complement receptor ...
Homo sapiens
Mol. Immunol.
105
150-164
2019
-
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3
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1
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1
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4
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753663
Zwarthoff
Functional characterization o ...
Homo sapiens
Front. Immunol.
9
1691
2018
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9
-
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2
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1
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1
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1
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4
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9
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755170
Di Fede
Neisseria heparin binding ant ...
Homo sapiens
PLoS ONE
13
e0194662
2018
-
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-
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1
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3
-
5
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1
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1
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753082
Berends
Molecular insights into the s ...
Homo sapiens
BMC Biol.
13
93
2015
1
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1
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732572
Lee
Aurin tricarboxylic acid self- ...
Homo sapiens
Neurobiol. Aging
34
1451-1461
2013
2
-
-
-
-
-
1
-
1
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1
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1
1
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732819
Alcorlo
Structural basis for the stabi ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
110
13504-13509
2013
-
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1
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2
2
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732056
Hebecker
Factor H-related protein 4 act ...
Homo sapiens
J. Biol. Chem.
287
19528-19536
2012
1
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1
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1
1
-
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732705
Okroj
Functional analyses of complem ...
Homo sapiens
PLoS ONE
7
e47245
2012
2
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2
-
1
1
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2
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1
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1
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4
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6
1
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1
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1
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4
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1
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1
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2
2
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717421
Camous
Complement alternative pathway ...
Homo sapiens
Blood
117
1340-1349
2011
3
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717427
Fridkis-Hareli
Design and development of TT30 ...
Homo sapiens
Blood
118
4705-4713
2011
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717660
Li
Essential role of factor B of ...
Mus musculus
Infect. Immun.
79
2578-2585
2011
-
1
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1
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717849
Hourcade
Access to the complement facto ...
Homo sapiens
J. Biol. Chem.
286
35725-35732
2011
-
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2
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2
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1
1
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707855
Lindorfer
A novel approach to preventing ...
Homo sapiens
Blood
115
2283-2291
2010
-
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709984
Strobel
Anti-factor B autoantibody in ...
Homo sapiens
Mol. Immunol.
47
1476-1483
2010
-
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1
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1
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710434
Laursen
Structural basis for inhibitio ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
3681-3686
2010
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2
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1
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717907
Martinez-Barricarte
Human C3 mutation reveals a me ...
Homo sapiens
J. Clin. Invest.
120
3702-3712
2010
-
1
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1
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717933
Luo
Secreted pH-regulated antigen ...
Homo sapiens
J. Immunol.
185
2164-2173
2010
-
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1
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718398
Forneris
Structures of C3b in complex w ...
Homo sapiens
Science
330
1816-1820
2010
-
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1
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1
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1
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701017
Torreira
3D structure of the C3bB compl ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
106
882-887
2009
2
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3
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2
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3
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1
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1
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707846
Heinen
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Roumenina
Hyperfunctional C3 convertase ...
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Activator-specific requirement ...
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Lutz
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Role of the alternative pathwa ...
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Mannan-binding lectin activate ...
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Huber-Lang
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Wiesmann
Structure of C3b in complex wi ...
Homo sapiens
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670220
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Structure and function of comp ...
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Williams
Dye-ligand affinity purificati ...
Homo sapiens
J. Immunol. Methods
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1993
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1
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Berkovich
Effect of N-methylation on the ...
Homo sapiens
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2
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Pangburn
The C3 convertase of the alter ...
Homo sapiens
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1986
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5
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5
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DiScipio
The activation of human comple ...
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1983
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36595
Gutierrez
An improved fluorogenic substr ...
Homo sapiens
Biochim. Biophys. Acta
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276-280
1983
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1
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1
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Vogel
The cobra venom factor-depende ...
Homo sapiens
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1982
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4
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4
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2
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1
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4
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36597
Kerr
Human factor B ...
Homo sapiens
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1981
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1
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